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Literature summary extracted from

  • Tiwari, V.; Clement, C.; Xu, D.; Valyi-Nagy, T.; Yue, B.Y.; Liu, J.; Shukla, D.
    Role for 3-O-sulfated heparan sulfate as the receptor for herpes simplex virus type 1 entry into primary human corneal fibroblasts (2006), J. Virol., 80, 8970-8980.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.30 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens modification of the heparan sulfate of glycoprotein D gD receptors required for entry of Herpes simplex virus simplex 1, 3-OST-3 and the herpesvirus entry mediator are involved, but not nectin-1 or nectin-2, in primary croneal fibroblasts, a natural target cell type, while HeLa cells use nectin-1 as the entry receptor, overview, 3-OS HS is required for HSV-1 glycoprotein-induced cell-to-cell fusion of cultured corneal fibroblasts adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
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 ?
2.8.2.30 additional information Homo sapiens HSV-1 glycoprotein-induced cell-to-cell fusion is inhibited by either prior treatment of cells with heparinases or by heparan sulfate preparations enriched in 3-OS HS, expression of HSV-1 gD in cultured corneal fibroblasts renders resistance to HSV-1 entry, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.30 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.30 corneal fibroblast cell line 3-OST-3 expression analysis Homo sapiens
-
2.8.2.30 fibroblast primary corneal, 3-OST-3 expression analysis Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.8.2.30 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.30 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
 Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate 3-OST-3 forms IdoUA2S-AnMan3S and IdoUA2S-AnMan3S6S disaccharides-containing products, product analysis, overview ?
2.8.2.30 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine modification of the heparan sulfate of glycoprotein D gD receptors required for entry of Herpes simplex virus simplex 1, 3-OST-3 and the herpesvirus entry mediator are involved, but not nectin-1 or nectin-2, in primary croneal fibroblasts, a natural target cell type, while HeLa cells use nectin-1 as the entry receptor, overview, 3-OS HS is required for HSV-1 glycoprotein-induced cell-to-cell fusion of cultured corneal fibroblasts Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
 ?
2.8.2.30 additional information HSV-1 glycoprotein-induced cell-to-cell fusion is inhibited by either prior treatment of cells with heparinases or by heparan sulfate preparations enriched in 3-OS HS, expression of HSV-1 gD in cultured corneal fibroblasts renders resistance to HSV-1 entry, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.30 3-O-sulfotransferase 3
-
 Homo sapiens
2.8.2.30 3-OST-3
-
 Homo sapiens